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High-salt diet does not boost neuroinflammation and neurodegeneration in a model of -synucleinopathy

79 Rather than depending on a single relay mechanism, extracellular ferroptotic propagation is likely mediated by a context-dependent signaling network whose dominant components vary with tissue architecture and disease state

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Circulating iron uptake in the form of two ferric iron (Fe 3+ ) bound to transferrin (TF) is achieved by binding to transferrin receptor protein 1 (TFR1) and subsequently triggering endocytosis [70]