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Patients with prior GERD, reflux-like symptoms, or related conditions were excluded to reduce bias

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Boxplots showing the concentrations (y-axis) of the significantly altered metabolites in control (n = 9), compared to 50 (n = 9), 35x6 (n = 9), and 4+1 (n = 9) treatment groups analyzed by one-way ANOVA, p-value 0.1)