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While tirzepatide has demonstrated greater benefits than semaglutide in other indications, in this study, only modest differences were observed for hospitalization for heart failure and mortality, which supports the use of either agent as an effective option. The study was limited by its nonrandomized design, leaving potential for unmeasured confounding despite propensity score adjustment

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Tirzepatide reduces body weight by increasing fat utilization via the central nervous system-adipose tissue axis in male mice

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