The nausea and vomiting reported by patients in the IGB only group may be explained by IGBs effect on gastric wall tension, which is influenced by factors of gastric wall stretch and tone [25]
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7 Still, Le, who is also a general surgery registrar at Royal Melbourne Hospital, says, I think it is too early to say this is a robust, durable, and generalizable effect given the high heterogeneity of underlying studies. He notes a need for more rigorous randomized controlled trials with longer follow-up times to better characterize the impact of these medications on weight and OSA together, as well as gain a better understanding of effect size, optimal doses, side effects, interactions with other medications, and impacts on other comorbidities
It also reviews research comparing oral and injectable delivery methods and outlines factors clinicians may consider when discussing compounded formulations