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Introduction / Class Entacapone is a COMT inhibitor (Catechol-O-methyltransferase inhibitor) used mainly in Parkinsons disease as an add-on drug with Levodopa/Carbidopa

The antioxidant properties help to protect the skin from UV-induced damage, reducing the risk of sunburn, photo ageing, and DNA damage

Phase 3 trials will test longer durations

Maximum concentrations are measured 2-4 hrs after the plasmatic peak

The medication is no longer on the FDA's drug shortage list

(496) indicates a significant reduction in both systolic as well as diastolic blood pressure, as well as decreases in whole cholesterol, LDL cholesterol, as well as triglyceride levels after the inclusion of dietary flavonoids