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Serious reactions are uncommon but include hypersensitivity and anaphylaxis, more often reported with parenteral thiamine

A recent study suggested that plasma levels of 5-MT, a compound related to serotonin metabolism, may be decreased in CFS patients, but this has been interpreted as a confounder caused by serotonin-selective reuptake inhibitor (SSRI) use in these patients ( The principal role of carnitine is to transport long-chain fatty acids into the mitochondria for energy production via beta-oxidation ( While carnitine supplementation could have benefits, some recent studies suggest that chronic oral L-carnitine administration may be associated with an increased risk for atherosclerosis via increased trimethylamine (TMA) and/or trimethylamine N-Oxide (TMAO) levels (58)

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They can also help with weight loss, and they are excellent for reducing stress and anxiety levels

Studies involving the injectable form are very rare indeed

Damevska K, et al