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Back to Journals Drug, Healthcare and Patient Safety Volume 18 Adverse Events Associated with Tirzepatide: Updated Pharmacovigilance Analysis Using FAERS (2022 Q1-2025 Q1) with an Adapted Time-to-Onset Method Authors Gu S Received 29 July 2025 Accepted for publication 3 January 2026 Published 8 January 2026 Volume 2026:18 556918 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Professor Siew Siang Chua Saisai Gu Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China Correspondence: Saisai Gu, Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China, Email [email protected] Purpose: Tirzepatide, the first dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist with rapidly expanding clinical use, requires detailed post-marketing pharmacovigilance to monitor emerging safety signals

Approximately 7% of participants in the Phase 2 clinical trial experienced skin sensitivity, compared to 1% in the placebo group