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The 2-Week Rule A helpful guideline many clinicians use is this: If a side effect appears for the first time after two weeks of stable treatment, or worsens significantly after the initial adjustment period, it deserves provider evaluation

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Choose a consistent time each day, before eating anything

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Clinical trials have demonstrated weight loss benefits across the dose range, and a lower tolerated dose that you can continue is preferable to discontinuing treatment entirely due to side effects

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A brain and nervous system (neurologic) examination helps confirm leg weakness and loss of sensation in the legs

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Are you comfortable with self-injection

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JON HALLBERG: Well, I have a personal story with one of my patients who, in-- I'll use the pronoun "they"-- they were on vacation and in their mid-80s, and took a gummy before going to bed just to sort of help with sleep-- woke up in the middle of the night, thick speech, felt very strange, a little out of body, woke up spouse, worried that this person was having a stroke, went to the hospital, got worked up, had an MRI, everything clear

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