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Some patients regain weight after stopping GLP-1 medication, especially if appetite returns and no maintenance plan is in place

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Participants without diabetes achieved weight reductions that exceeded expectations for medications targeting only one receptor, while those managing type 2 diabetes saw improvements in both blood sugar control and body composition

However, there is no evidence that stimulant-based ingredients are effective when delivered through the skin, and it remains unclear whether they can be absorbed in sufficient amounts to produce meaningful effects

t is important to note that low levels are rare in most healthy adults because the human liver stores several years worth of vitamin B-12

doi: 10.3389/fnins.2025.1623485 Received 06 May 2025 Accepted 16 October 2025 Published 11 November 2025 Volume 19 - 2025 Edited by Antimo Cutone, University of Molise, Italy Reviewed by Francisca Prez-Severiano, Instituto Nacional de Neurologa y Neurociruga MVS y, Mexico Yanbo Shi, Jiaxing Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, China Updates Copyright 2025 Long, Zhu, Zhao, Liao and Liu