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304 Gene therapy approaches have been employed to cure PK deficiency in dogs

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Under pathological conditions, mitochondrial damage not only promotes translational activation of ATF4, but also induces transcriptional upregulation of the ROS-p38 MAPK-activating transcription factor 2 (ATF2) signaling axis driven by FGF-21 [102]

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Without adequate carnitine, even mobilized fat stores struggle to enter the metabolic pathway that generates energy

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