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Reduction in senescent cell concentration, which otherwise contribute to inflammation and tissue damage

Vitamin B12 is a water-soluble vitamin, meaning the body excretes any excess through urine rather than storing it

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Foundational Discovery Selective Senolytic Elimination in Aged Mice (Cell, 2017 Baar et al.) FOXO4-DRI Restores Fitness, Fur Density, Renal and Liver Function in Aged Mice The foundational study introducing FOXO4-DRI as a senolytic peptide was published in Cell by Baar and colleagues in 2017