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Ambrosio, M
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Clinical evidence demonstrates that oral doses of 13 grams per day, administered for 612 months, can reduce neuropathic pain scores, with enhancements in nerve fiber regeneration and sensory function, particularly when combined with standard therapies [5]
In the inflamed brain, NGF-overexpression is induced in neurons and glia cells (84)
Alternatively, different formulations of lipid NPs loaded with Tacrine or conjugating Tacrine with model amphipathic peptide (MAP) showed high encapsulation efficiencies, low cytotoxicity in the neuroblastoma cell line SH-SY5Y and thus improved therapeutic efficacy as potential drug delivery systems (Silva et al., 2020)
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