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Less common but serious side effects include constipation, which can lead to skin issues such as bleeding and blistering, or burning feeling in the mouth

206 In a placebo-controlled trial, 60 patients with stage 4 CKD who had been eating a low-protein diet for two months were assigned to add probiotic supplements providing 1 billion CFUs L

Shown below in rank order, worst to best vis-a-vis GI side-effects are the six GLP-1 groups