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Gastrointestinal side effects and fluid balance: Nausea : Very common, affecting approximately 20% of patients

Evidence level is high based on confirmed Phase 3 data

Over time, these processes have led to the emergence of many superbugs. For example, surveillance data show that 42% of Escherichia coli isolates worldwide are resistant to third-generation cephalosporins and 15% of Staphylococcus aureus isolates are methicillin-resistant (MRSA) in elderly individuals

In a recent study, it was shown that patients with asthma who were well controlled with inhaled corticosteroids and long-acting 2 agonists had higher lipid peroxide levels compared with healthy controls [113]

Several enzymes involved in ATP production contain Fe-S clusters in the active site and are subject to similar inactivation by superoxide, including oxoglutarate dehydrogenase of the tricarboxylic acid cycle, as well as ETC complexes IIII

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