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Results Here we show that metformin is the most promising therapy for protection against AD, while semaglutide ranks among the least effective, based on comparative analysis within the DM2-AD pathway-pathway comorbidity network

GLP-1 receptor agonists are commonly added to a diabetes treatment plan when other medications are no longer enough to maintain good control, or when patients require more insulin

Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4/NF-B pathway

However, GGC consists of a gamma-glutamyl bond which makes it resistant to hydrolysis by endoproteases (Anderson and Meister, 1983)

Beyond glycemic control, GLP-1 receptors are distributed throughout the body, including in the central nervous system

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