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The activation of mast cells caused the destruction of neighboring chondrocytes and the breakdown of cartilage.[ref] Related article: Osteoarthritis genes The figure below is from a study on mast cells in osteoarthritis (OA), showing both increased numbers of mast cells and an increase in tryptase

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Other symptoms: These can include headaches, irritable bowel syndrome, anxiety, depression, and temporomandibular joint (TMJ) disorders