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A method for chronic weight management in a subject with an initial body mass index (BMI) that is less than or equal to 27 kg/m 2 , wherein the subject has at least one weight-related comorbidity, comprising administering a once weekly tirzepatide selected from the group consisting of 20 mg tirzepatide or a pharmaceutically acceptable salt thereof, and 25 mg tirzepatide, or a pharmaceutically acceptable salt thereof
By persistently activating GLP-1 receptors, these drugs provide a constant signal of fullness to the brain, leading to a significant reduction in calorie intake and subsequent weight loss
however, dedicated cardiovascular outcome trial (CVOT) data have not yet been published, and cardiovascular benefit has not been demonstrated Phase 3 trials are ongoing
Retatrutide (LY3437943) is a peptide developed by Eli Lilly that acts on three different metabolic receptors simultaneously: GLP-1 receptor GIP receptor Glucagon receptor This makes Retatrutide the first triple-agonist peptide to reach advanced Phase 3 clinical development
Adems, algunos pacientes no toleran bien el frmaco y debe reducirse la dosis o incluso suspender el tratamiento
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