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However, nearly all data come from lab and animal studies rather than controlled human trials, so claims about systemic hormone changes warrant caution

Topical calcineurin inhibitors are regarded as safe for short-term or intermittent long-term use, although they are generally less effective than corticosteroids

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You can reduce that risk by keeping bowel habits regular and monitoring your blood glucose if you are diabetic or pre-diabetic

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Fat tissue converts testosterone to estrogen through an enzyme called aromatase