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The overactivation of ERK signaling is involved in autophagic flux disruption (117)

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The authors concluded that tesamorelin might be beneficial in people with HIV and fatty liver disease but stated that further research was needed to determine its long-term effects on liver histology. Why it matters Why it matters These findings suggest that GHRH and GH-axis stimulation may influence ectopic-fat storage in addition to abdominal VAT

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Luminescence was recorded for 45 min at 1 min intervals using a Fluoroskan Ascent FL (Thermo Scientific, Rockford, IL, USA) fluorimeter (excitation: 538 nm, emission: 604 nm), and the slopes were used for calculations