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In the SURPASS-2 study, the three doses of tirzepatide (5, 10, and 15 mg once weekly) were tested with the GLP-1RA semaglutide (1 mg once weekly) as a comparator in patients not optimally controlled on monotherapy with metformin (71)

The findings are attention-grabbing not only because of the size of the dataset, but because they suggest these agents may have effects that extend beyond glycemic control and weight loss

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All botulinum toxin products, including Xeomin, have a Boxed Warning from the FDA about the toxin spreading from the treated area