52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA
GLP-1 medications have demonstrated significant cardiovascular benefits the SELECT trial showed semaglutide reduced major cardiovascular events (heart attack, stroke, cardiovascular death) by 20% in high-risk patients
The good news: fall and winter can be the best time to correct sun damage because youre typically getting less direct sun exposure day to day
If you are taking a supplement that is 90% destroyed in the stomach, you aren't getting the cellular support you paid for
Someone with mild obesity and good GLP-1 tolerance might succeed with microdosing at $129/month
How long does it take to start treatment