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DFP is effective for long-term iron chelation therapy for transfusion iron overload in conditions like thalassemia and sickle cell disease (Pennell et al., 2006), potentially due to its low molecular weight and lipophilicity, which allow it to more easily penetrate myocardial cells and remove intracellular toxic labile iron stores (Pennell et al., 2011
PMC 4084863
32 A fatty acid chain attached to Lys 20 in tirzepatide may boost the GLP-1 activity while the GIP activity remains unaffected
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Side Effects Gastrointestinal symptoms: Most common adverse effects were mild-to-moderate nausea, vomiting, and diarrhea, occurring primarily during dose escalation [6] [12]
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