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Amylin/calcitonin receptor-mediated signaling in POMC neurons influences energy balance and locomotor activity in chow-fed male mice
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Suzuki K, Hatzikotoulas K, Southam L, et al
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Event Phase 2 Rate (12 mg group) Phase 2 Rate (Placebo) Nausea 45.8% 11.6% Diarrhea 33.3% 9.3% Vomiting 22.2% 2.3% Constipation 16.7% 7.0% Decreased appetite 22.2% 2.3% The nausea incidence at the highest dose a nausea percentage of roughly 46% makes it the single most reported adverse event in retatrutide clinical trials 2026 data
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