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Here's what that looks like in practice: you're faithfully in a caloric deficit
Reviewed by: WPG Research Team, Health & Wellness Editor Last Updated: February 7, 2026 | Sources: NEJM, Nature Medicine, Eli Lilly, FDA.gov, ClinicalTrials.gov The Bottom Line on Retatrutide Retatrutide shows among the highest weight loss results reported in any Phase 3 obesity drug trial to date (~28.7% body weight at 68 weeks)
Consequently, semaglutide users may represent a subgroup with greater metabolic burden, introducing selection pressures not fully mitigated by our design