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One issue to be solved may be the differential expression patterns of SGLT-2 in CNS between human and rodents, although some studies have attempted to describe central distribution and the related function

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Therefore, drugs with a potent antihyperglycemic effect, independent of the glomerular filtration rate, with a low risk of hypoglycemia, that reduce weight in overweight/obese patients and that provide cardiovascular and renal protection, such as GLP-1 receptor agonists, are needed

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