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Clinical trial data for FDA-approved GLP-1 receptor agonists demonstrates: Significant weight reduction: Meaningful mean body weight reduction in trial participants (see FDA-approved labeling for specific approved products) Cardiorenal protection: Reduced risk of major adverse cardiovascular events and kidney disease progression Improved lipid profiles: Decreased triglycerides and increased HDL cholesterol Blood pressure reduction: Modest but clinically significant decreases in systolic blood pressure Reduced inflammation: Decreased inflammatory markers associated with metabolic syndrome Note: Clinical outcomes cited above reflect published trial data for FDA-approved GLP-1 receptor agonists

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doi: 10.1074/jbc.M112.421073 50 AbramiLAudagnottoMHoSMarcaidaMJMesquitaFSAnwarMUet al

Liraglutide Protects Against Amyloid- Protein-Induced Impairment of Spatial Learning and Memory in Rats

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Diabetes Care 41, 26692701