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Based on the available data, tirzepatide has the lowest discontinuation rates and similar or slightly lower GI side effect rates compared to semaglutide
Nature Obesity, online ahead of print
[4] [5] Concomitant medications generally do not affect tirzepatide absorption since it is administered subcutaneously, bypassing gastrointestinal absorption
Your prescribing provider can assess whether your current plateau or side effect profile suggests a switch would be beneficial
Compounded medications are not reviewed or approved by the FDA for safety or effectiveness
However, not all people with B12 deficiency have the same number, variety or severity of symptoms
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