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I have this mental image of them as a pressure tank with a bunch of angry electrons all crammed inside about to burst out

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is supported by NIH research grants R01MD014712, U2CDK114886, UL1TR002319, U54DK083912, U01DK100846, OT2HL161847, UM1AI109568, OT2OD032581 and CDC project numbers 75D301-21-P-12254 and 75D301-23-C-18264