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1), thiols (cysteine and GSH) can react with L-dopaquinone to produce glutathionyldopa, or act as a reservoir of L-cysteine by conjugating with L-dopa-quinone to produce cysteinyldopa

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High levels of body fat especially visceral fat surrounding internal organs increase the likelihood of insulin resistance and type 2 diabetes and contribute to hypertension, high cholesterol and an increased risk of cardiovascular diseases such as heart attack and stroke

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Mechanisms identified include: increased cardiac utilization of ketones increased autophagy (recycling of intracellular components)l decreased inflammation & oxidative stress improved mitochondrial function decreased intracellular Ca & Na overload decreased fibrosis improved myocardial diastolic function decrease myocardial hypertrophy Figure: Mechanism of action of action of SGLT-2 inhibitors in the kidney

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