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Healthcare providers generally consider inositol safe when taken in low doses for up to 10 weeks

MATERIALS AND METHODS The current study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension statement for the reporting of systematic reviews incorporating NMAs of Health Care Interventions (Supplementary Material 10) [28]

sustained growth-hormone-axis stimulation also carries a theoretical, class-wide concern for worsened insulin resistance, a recognized effect of excess growth hormone exposure generally Evidence snapshot: The strongest available evidence is a small 1997 randomized, placebo-controlled human trial (19 adults aged 55-71) testing a closely related GHRH(1-29) analog over 16 weeks, which found increased IGF-1 in both sexes, a significant lean-mass increase in men only, and increased skin thickness in both sexes

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Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis