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A 2003 double-blind placebo-controlled trial by Humbert and colleagues in Experimental Dermatology applied 5% topical ascorbic acid cream versus vehicle to the low-neck and arms of healthy women with photoaged skin for 6 months, with assessments at baseline, 3 months, and 6 months, and found that active treatment improved skin relief and silicone-replica topography and produced favorable changes on end-of-study immunohistochemistry and electron microscopy of dermal biopsies biopsy-level evidence of structural remodeling, not merely surface appearance
Subcutaneous Aqueous drug particle suspension 1
muciniphila following metformin treatment in obese mice activated regulatory T-cells in visceral adipose tissue
doi: 10.1093/hmg/ddaa273 45 MacDonaldJ
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