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Manufacturer: Vitex Pharmaceuticals Pty Ltd, 4 Alspec Pi, Eastern Creek Nsw, Australia 2766
Glutathione can be taken as an oral supplement, but it is very poorly absorbed
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To induce intracellular GSH depletion, cells were incubated in Cys 2 -free medium or with BSO (1000 M) treatment or erastin (10 M) treatment

Glutathione supplementation supports thyroid health by reducing the need for selenium and providing the thyroid cells with an oxidative stress regulation tool they natively use.* Glutathione helps to recycle glutathione peroxidase, removing the toxic products the enzyme captures.* This means the thyroid cells will not need to produce extra glutathione peroxidase to cope with oxidative stress.* Additionally, glutathione neutralizes ROS directly, independent of the antioxidant-enabling activity it performs for glutathione peroxidase.* Using a glutathione supplement can thus modify the threat model of thyroid issues from selenium insufficiency or excess oxidative stress.* Rather than an individual with compromised thyroid function worrying about both impaired hormone production and thyroid damage, they would only need to be mindful of maintaining a minimum viable level of oxidative stress to provide for essential functions (although it is highly unlikely to fully deprive thyroid cells of the baseline level of oxidative stress they need to produce hormones)
