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Key mechanisms include: Activation of neurons in the area postrema and nucleus tractus solitarius in the brainstem Enhanced satiety signaling through distinct pathways from GLP-1 mechanisms Slowed gastric emptying via calcitonin receptor-mediated effects Reduced food reward signaling and decreased food noise through central appetite centers Studies in knockout mouse models confirmed that cagrilintides weight loss effects depend specifically on AMY1R and AMY3R presence, demonstrating receptor-specific mechanisms
They are also beneficial for those with type 2 diabetes, as they address both blood sugar levels and weight concerns
A 1,000mg capsule that doesnt absorb is worth less than a 500mg effervescent that does
Dhruv Khullar about how GLP-1s affect the brain, its reward system, and maybe even addiction
10 McEwen Centre for Regenerative Medicine, and 11 Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada