Yes, alcohol addiction increases the risk of alcohol poisoning by promoting frequent binge drinking, higher tolerance, and impaired self-regulation
Metabolic pathways: B12 is a cofactor in two critical reactions: Methylmalonyl-CoA mutase: Converts methylmalonyl CoA (from odd-chain fatty acids and some amino acids) into succinyl-CoA, which enters the Krebs (TCA) cycle to make ATP (cellular energy)
This is supported by metabolomic profiling studies that have identified complex lipid species and amino acid analogues associated with the response to weight loss interventions
10.1016/j.freeradbiomed.2015.12.024 76 PapackovaZ.HeczkovaM.DankovaH.SticovaE.LodererovaA.BartonovaL.et al (2018)
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The kidney expresses GGT at the highest levels, while notable expression is also found in bile canaliculi of hepatocytes, ducts within the pancreas, the apical surface of the intestinal epithelium and the luminal surface epithelium of many reproductive organs (25)
