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Gastrointestinal Effects of GLP-1 Receptor Agonists: Mechanisms and Clinical Implications
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(44) reported that both GIPR agonist (GIPRA) and dual GIP/GLP-1 receptor agonist similarly improved glucose tolerance in GLP-1R knockout mice, but not in dual incretin receptor knockout mice
By mimicking the natural hormones GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory polypeptide), tirzepatide not only enhances insulin secretion in response to meals but also reduces appetite, making it easier for patients to achieve and maintain a healthier weight