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in Thyroid found that combination T4 and T3 therapy improved quality of life in some patient subgroups who felt undertreated on levothyroxine alone

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Additionally, individuals taking medications that may interact with B12, including metformin or proton pump inhibitors, should consult a healthcare provider before starting supplementation

DOI: 10.1021/acs.jmedchem.1c00565 Lau J, Bloch P, Schffer L, Pettersson I, Spetzler J, Kofoed J, et al