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in patients with T2DM (38) found that continuous GLP-1 administration via a subcutaneous pump to raise serum GLP-1 levels from a mean of 9.7 pM at baseline to 282 pM over 6 weeks significantly reduced plasma glucose concentrations, improved glycated hemoglobin, and enhanced insulin sensitivity and -cell function compared to placebo, with no significant limiting side effects reported

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The project is funded by a new five-year, $3 million grant from the National Institute of Neurological Disorders and Stroke

Proceedings of the National Academy of Sciences of the United States of America , 115(10), E2320E2328

Since then, there have been a lot of reports on the actions of IGF-I and its receptor (IGF-IR) and binding proteins (IGFBPs) in regulating biological functions in both physiological and pathological states