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The PhoA activity was calculated using equation [3]: with AU being arbitrary units, Abs being the absorption at 420 nm and 550 nm and OD 600 being the culture optical density at 600 nm

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Furthermore, mechanical ventilation is a risk factor for cerebral inflammation and brain injury due both to the pulmonary inflammatory cascade, which migrates systemically to the brain, and to hemodynamic instability for the reduction in cardiac output and high pulmonary resistance caused by the distension of alveoli and compression of pulmonary capillaries 132

Glossary 3Tg mouse model of Alzheimer disease Mice that harbour the human APP transgene containing the Swedish mutation, a PSEN1 knock-in with the M146V mutation and the MAPT transgene containing the P301L mutation