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Following a 12 h incubation period, the 143B cells were incubated with PBS, Ru(II)-OH, NP2, or NP4 (10 M Ru) for 6 h

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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

Deutsche Forschungsgemeinschaft CO 291/7-1(M.C.)

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(Source 3) Vitamin C is also important for glutathione generation, both dietary and supplemental vitamin C