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Furthermore, due to questionable significance of animal data and ethical opposition to animal testing, effort has been to put into finding alternative testing methods to identify potential skin toxins 17,18,19

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Indeed, we observed similar circulating concentrations of sLRP-1, various pro-inflammatory cytokines including TNF-, and free cholesterol, which suggested that disruption of circulating ligand trafficking 64 , peripheral inflammation 65 , and cholesterol homeostasis 66 , respectively, did not occur at endpoint despite the marked effects on hepatic LRP-1 concentrations

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