surmount-1 tirzepatide trial obesity without diabetes vs semaglutide: A new battle in treatment Tirzepatide Was Associated with Improved

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Case example : A patient receives wireless capsule endoscopy of the small intestine

1,2 The results are consistent with actions taken by the European Medicines Agency (EMA) in June 2025, when the agency classified NAION as a very rare side effect of semaglutide and recommended product labeling updates. Epidemiologic data reviewed by the EMA suggested an approximately twofold increased risk in adults with type 2 diabetes, corresponding to roughly one additional case per 10,000 person-years of treatment. The agency advised that patients with sudden vision loss or rapidly worsening eyesight seek immediate medical attention and discontinue treatment if NAION is confirmed. READ MORE: Blinding Disease-Weight Loss Drug Link: EMA Announces Start of Semaglutide Investigation Study strengths Methodologically, the VA study offers several strengths: The analysis leveraged the largest integrated health care system in the United States, with medication exposure confirmed through pharmacy dispensing records rather than prescription data alone

Some note initial mild tingling from AHA, which fades with continued use

doi: 10.4081/ija.2021.1851 88 GodoyD.DewbreJ.P.AmegnagloC.J.SogloY