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The REDEFINE1 Phase 3 trial showed 22.7% weight loss over 68 weeks in adults with obesity/overweight (no T2DM), exceeding the 20.2% seen with tirzepatide in SURMOUNT5
The preparation was not necessarily equivalent to pure emideltide, and a mouse lifespan experiment cannot establish anti-ageing or cancer-prevention effects in humans
[1] The data is clear that these medications do a lot of good
Furthermore, a newer 2021 study on the effect of Melanotan 2 on mice showed that when injected, MT-II increased satiety
Conclusions The antifibrotic effects of GLP-1R activation on pulmonary fibrosis could be attributed to the inhibition of the interaction between NLRP3 inflammasome and PFKFB3-driven glycolysis, and histone lactylation in lung fibroblasts
