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Rantanen, J., & Fatouros, D

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Therefore, when the level of ATP is high, conversion of glutamate to alpha ketoglutarate is limited

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519 Specifically, high blood glucose-induced insulin resistance in CRC cells leads to increased BMP4 expression, which activates the BMP4-Smad1/5/8 signaling pathway

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By activating both glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors, it boosts insulin secretion and enhances appetite suppression, often leading to even greater weight loss (Jastreboff et al., 2022)

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doi: 10.1210/clinem/dgab722 38 WillardFSDourosJDGabeMBShowalterADWainscottDBSuterTMet al

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