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Cronin M, Ross JS

In one animal study, knock-down of GLP-1Rs in the brain neurons almost eliminated the effect of liraglutide, whereas knock-down of GLP-1Rs in the peripheral nervous system did not alter its efficacy significantly (185)

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To me, this is a clear-cut issue: the prevention of major cardiovascular eventsbe it cardiac or strokewith GLP-1s, Howard Feldman, a professor of neurosciences at the University of California San Diego, said

Interestingly, gastric sleeve surgery itself increases natural GLP-1 production, which contributes to its weight loss effects

If I were speeding up without sleep, Id be worried