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EVs carry ligands (e.g., Epidermal Growth Factor, Fibroblast Growth Factor)) that bind to receptor tyrosine kinases on neurons, activating downstream signaling pathways that regulate neuronal growth and differentiation (78)

Incretin Hormones Hormones released by the gut after eating that stimulate insulin production and reduce blood sugar

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While more research is needed to determine the full range of benefits and use cases for semaglutide in knee pain, new findings about its potential to aid with knee osteoarthritis are exciting