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Subcellular localization Deciphering the subcellular localization of all these proteins should also contribute to the understanding of their biological role

Its unique -glutamyl linkage rather than the standard -peptide bond between Glu and Cys confers resistance to most peptidases and extends its intracellular half-life substantially

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For a 75 to 90kg adult, that translates roughly to 190 to 900mcg daily, which brackets the 200 to 500mcg range being used in practice

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In addition to its analgesic and anti-inflammatory effects, PEA is also thought to offer neuroprotection by reducing the levels of reactive oxygen species and by modulating cell death pathways