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M.PerroyJ.LollF.PerraisD.FagniL.BourgeronT.et al (2012)

Curr Genet 59: 91106

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V4: Rate of uncoupled respiration (state IV), representing oxygen consumption rate after ADP has been consumed

GSH production is supported by NRF2 through controlling several enzymes responsible for GSH synthesis, such as the glutamate-cysteine ligase (GCL) complex composed of two subunits, the modifier (GCLM) subunit and the catalytic (GCLC) subunit, which catalyze the rate-limiting step of GSH synthesis that converts cysteine and glutamate into GSH [22]