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Their clinical benefits in cardiovascular and renal outcomes have been demonstrated in large randomized trials such as EMPA-REG and CANVAS [11, 12]

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In vivo [D- 13 C 6 ]-glucose administration for stable isotope tracing [D- 13 C 6 ]-glucose (Sigma: #389,374) was dissolved in sterile PBS to prepare 5% (w/v) solution

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