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We believe that this limited contribution and non-essentiality of caspase-3 for the execution of eryptosis is associated with the absence of the upstream mitochondrial pathways in mature erythrocytes linked with the expulsion of this particular organelle at the terminal stages of erythropoiesis, as well as downstream effectors

Biochemical and Biophysical Research Communications, 54(2), 562-566

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From that, eventually, the pharmaceutical drugs exenatide, liraglutide, semaglutide, and tirzepatide were developed

Burgmaier M, Liberman A, Mllmann J, Kahles F, Reith S, Lebherz C, et al

For the colorectal cancer PDX study, female NCR nude mice (CrTac:NCr- Foxn1 nu from Taconic) were implanted subcutaneously with low-passage KRAS-mutant CRM 13180 tumour fragments (30 mg) into the region of the right axilla