Meeting Highlights From the Pharmacovigilance Risk Assessment Committee (PRAC) 811 April 2024
The GSH levels of the BSO-treated cells quantified using our RT-based flow cytometry method is well correlated to the values measured using cell lysates with a glutathione reductase-based biochemical assay ( R 2 =0.99, Fig
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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
The data are extremely limited, although they give us reason to be curious about the potential for GLP-1 RAs for BED, she told Medscape Medical News